Hand, foot and mouth disease gets its name from the non-itchy rash that develops on the palms of the hands and soles of feet. HFMD is a different infection from the infection of cattle, sheep and pigs called foot-and-mouth disease. (). Hand, foot and mouth disease (HFMD) is due to an infection that usually causes a typical illness, including a typical rash. It is most commonly caused by the Coxsackie A16 virus. Some cases are caused by a different but related virus called enterovirus Rarely, the same illness is caused by other strains of Coxsackievirus. Hand-foot-and-mouth disease is usually a minor illness causing only a few days of fever and relatively mild signs and symptoms. Contact your doctor if mouth sores or a sore throat keep your child from drinking fluids. And contact your doctor if after a few days, your child's signs and symptoms worsen.